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As a result, surface expression of B2M and class I HLAs is reduced, helping the virus evade identification and clearance of infected cells by cytotoxic CD8+ T cells (138, 158, 159)

Prolonged systemic use can also cause hypothalamic-pituitary-adrenal (HPA) suppression or signs/symptoms of Cushings syndrome (marked by high cortisol levels)

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When were young, these systems operate with remarkable precision, but over time, the signals that keep them running efficiently break down

The model estimates the state of CS, allowing, also, to appreciate its variation over time (Sun et al., 2019)