doi: 10.1021/AM502537K 116 MihajlovicM.LazaridisT
Van Leyen, K., Duvoisin, R
(Thermo Fisher Scientific)

For the individual looking for raw size, there are a couple of solid options when considering IGF-1 use. Many will use it during their course of anabolic steroids, which will only enhance the rate in which lean tissue is built, as well as the amount. Others, and this is typically for more advanced bodybuilders, will use it during a bridge period. A bridge refers to a period of time in-between anabolic steroid cycles or full blown cycles. In this case, the individual will continue using a maintenance dose of testosterone and add in the IGF-1. Many who do this are also using HGH and simply continue it from their cycle that just ended into the bridge that just began. Regardless of your specific time of use, during cycle or as a bridge, the use of HGH is normally advised. IGF-1, while powerfully anabolic also has the ability to promote excess fat storage. During an off-season bulking stage, maintaining proper body fat levels is hard enough on its own, and its only complicated by the use of IGF-1. However, when we include HGH the metabolic boost it provides should be enough to keep things under control. Further, the synergy between these two hormones is remarkable
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Curr Opin Struct Biol 65:102109 Davidson IF, Peters JM (2021) Genome folding through loop extrusion by SMC complexes