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The mTORC1 inhibition by AMPK is accomplished by direct phosphorylation of the regulatory-associated protein of mTOR (Raptor) [264] and indirectly via activation of TSC2 [265, 266]

KEY POINTS TO REMEMBER Treatment of lipid disorders should be initiated in childhood, since delaying therapy to adulthood may lead to development of cardiovascular diseases as early at a young age

Curran CS, Kopp JB (2023) The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease