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For example, the genetic changes introduced by gene editing can be passed on to future generations through germline modification, which may lead to unforeseeable genetic complications or ecological impacts on the human gene pool

RA CD4 + T cells lose tolerance decades before joint inflammation begins, while living in lymphoid organs, such as lymph nodes and the bone marrow

Retrieved June 6, 2024, from Watanabe, J

Synovial T cells are involved in the induction of antibody production and local inflammation (198)