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In another example, cyclophilin D, an important component of mitochondrial permeability transition pore, was observed to be overexpressed and oxidatively modified when stimulated by oxidative stress in affected brain tissue and skin-derived fibroblasts from patients with X-ALD as well as the spinal cord of X-ALD mouse models

(1988) Proc

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438,439 GLP-1 can also enhance endothelial function by promoting the production of NO, possibly through activating eNOS, thereby affecting vasodilation, anti-inflammatory actions, and anti-atherosclerosis