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The body mounts an immune response to the prolonged irritation and oxidative stress from tobacco smoke that, over time, can lead to permanent changes to the lungs, including widening of the air sacs, excessive mucous secretion, and stiffening of the smaller airways [40]

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If youre ever unsure, err on the side of caution: use one pouch, wait at least an hour or two, and assess how you feel before reaching for another