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Without enough manganese in the body to maintain the activity of manganese superoxide dismutase, the balance between the production and breakdown of superoxide is compromised and the oxidants begin damaging cells in the liver

Curr Opin Microbiol 17:5360 Upadhyay A, Upadhyaya I, Mooyottu S, Venkitanarayanan K (2016) Eugenol in combination with lactic acid bacteria attenuates Listeria monocytogenes virulence in vitro and in invertebrate model Galleria Mellonella

(E and F) Cisplatin-induced cell viability and cytotoxicity assay using calcein AM and ethidium homodimer (EthD-1) fluorescence staining with confocal microscopy (E) and flow cytometry (F)

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Conversely, detraining inhibits this pathway, resulting in increased oxidative stress and ferroptosis, ultimately compromising muscle mass and function, leading to muscle atrophy