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We demonstrated that inhibition of autophagy worsened the senescence phenotype of vitiligo melanocytes, as revealed by an increased expression and nuclear translocation of p53, a higher expression of its target gene GADD45 and by elevated levels of p21 and p16

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Molecular analyses reveal that 5-amino-1MQ administration alters expression of key genes involved in epithelial-mesenchymal transition, including increased ZEB1 and SIRT1 expression alongside decreased TWIST and SERPIN1 levels

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