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When these two pathways are activated simultaneously, the effect is multiplicative: GHRH increases the amount of GH released per cell, and GHRP increases the number of responding cells

J Biol Chem 285:1830918318

Shh expression, previously identified to be critically important for embryonic notochordal cell differentiation, was found to be significantly downregulated in early postnatal NP cells (Peck et al., 2017)