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2) acetoacetate is further activated to acetoacetyl-CoA by 3-ketozcid CoA transferase 1 (SCOT1)

V., & de Castro, H

456 However, we recommend caution against excessive elevation of BCAAs as BCAAs imbalance is associated with detrimental health consequences, including hyperphagia, metabolic disorders, cardiovascular diseases, and reduced lifespan

Due to the risk of Type I error, small subgroup sizes, and substantial heterogeneity, the results should be interpreted cautiously and require confirmation in future well-designed studies

However, it is widely accepted that HO-1 is a heat shock protein that is controlled by inflammatory or pro-oxidant states and is induced in various pathologies in response to oxidative stress [1]