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In an important study by Khokhar and Tyndale, the authors found that 7 days of nicotine treatment increased CYP2B expression in the brain, but not liver, and surprisingly, this change in metabolism was sufficient to potentiate the sleep-inducing effects of the general anesthetic propofol in male rats (167)

The second study involved 20 cats exposed to SHS, alongside a control group, all presented for routine clinical examination and vaccination to a veterinary hospital 4

Replicates tobacco flavour of a cigarette Strength: 5mg, 11mg or 20mg 2