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In general, MIF reduces the CS-induced apoptosis of pulmonary vascular endothelial cells by inhibiting the signal transduction of the ASK1-P38-XOR pathway (Table 2)

As between-study heterogeneity can be underestimated or even zero when the number of studies is small 196,197 , we used Fishers information matrix to estimate the uncertainty of the heterogeneity 198 and incorporated that uncertainty into the final results

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