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In accordance with these results, upregulation of filaggrin was also observed in oral keratinocytes of smokers 19 , in keratinocyte cell cultures 19, 20 or in reconstructed human epidermis 21 exposed to cigarette smoke extract, and porcine skin explants exposed to cigarette smoke (our unpublished data)

In FY 1990, the states business profits tax (BPT) constituted the single largest source of tax revenue, generating some $180 million (in constant FY 2009 dollars) or approximately 22 percent of total tax revenue

Twelve states (not Kansas), the District of Columbia, Puerto Rico and 752 localities have expanded their smoke-free air laws to also prohibit e-cigarette use in places where cigarette smoking is prohibited, such as restaurants, bars and worksites

Members could read messages and, in some cases, were also able to react through comments

Such variants are characterized by a distinctive design, higher quality tobacco, and smaller editions