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[12] [13] E-cigarettes containing nicotine are more effective than nicotine replacement therapy (NRT) for smoking cessation, [14] [15] [16] but have not been tested as rigorously as nicotine replacement therapy products

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Factors Contributing to Vaping Popularity There are several reasons why vapes may be appealing to youth compared to other nicotine and tobacco products

Although this isoform is not directly related to drug metabolism, it is associated with liver dysfunction due to the accumulation of bile acids, which could disrupt enterohepatic recirculation and, therefore, indirectly affect drug metabolism (Zhang et al., 2015)