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Decisions will need to be made about whether e-cigarettes should benefit from differential tax policy, marketing regulations and, perhaps most knotty, where they can be used

They may also develop a tolerance to it, which means they need to take larger amounts of nicotine to get the same effect

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Initially, insulin resistance is compensated by increased insulin secretion, but over time, -cell dysfunction and diabetes can develop (Galicia-Garcia et al., 2020)