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Despite the deadly nature of smoking, there has been great hostility to the development of clean nicotine alternatives

Quantitative variables are presented as mean with standard deviation (SD) or median and interquartile range (IQR), as appropriate

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We also do not know whether the severity of dependence is associated with improvement in negative symptoms because we did not assess it with the Fagerstrom Test for Nicotine Dependence (FTND) in the present study

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