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Similarly, the expression of key autophagy genes, such as ATG5 , ATG7 , and BECN1 , is downregulated during normal aging in the human brain [209]

This content is for educational purposes only and does not replace professional medical advice

Evidence from COPD animal models shows that chronic alveolar hypoxia leads to pronounced microglial activation in the hippocampus and cortex, correlating with cognitive deficits and mood alterations [39, 58] (Fig