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Excess H 2 O 2 has been demonstrated to inactivate thyroid peroxidase in vitro, suggesting that its accumulation could also affect TH [32] (Figure 1)

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GHK-Cu is a tripeptide - just three amino acids (glycine, histidine, lysine) bound to a copper ion

Since monotherapy with metformin, PPIs, or HRAs, has been demonstrated to significantly deplete vitamin B 12 independently, co-prescription of these medications might induce an additive effect

Although these developments are encouraging, issues with safety validation, standardization, and legal frameworks still exist