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Interestingly, nicotine has been demonstrated to regulate processes such as immune evasion, proliferation, metastases, and stem cell-like characteristics via immune checkpoints in association with nAChR receptors in the cancer context (72)

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Figure 1 The ubiquitination process involves a series of enzymes: the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3) (3537)

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