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Cells in the multiple sclerosis central nervous system: trafficking and contribution to CNS-compartmentalized inflammation

Evidence supports crucial roles in regulating inflammation, appetite, mood, and the stress response (167)

doi: 10.3389/fimmu.2022.946119 27 JacobsSRHermanCEMacIverNJWoffordJAWiemanHLHammenJJet al

Finally, to ensure that the depletion of serum B 12 levels and its associated low levels of Met were not simply caused by defective oral uptake due to the reprogramming of several digestive organs, we administered a large bolus of vitamin B 12 (5 g per mouse, 100 times the recommended dietary allowance 41 ) on day 6 of doxycycline treatment, 1 day before euthanasia (Fig