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Chen M, Wang F, Cao JJ, Han X, Lu WW, Ji X, Chen WH, Lu WQ, Liu AL (2019) ()-Epigallocatechin-3-gallate attenuates the toxicity of methylmercury in Caenorhabditis elegans by activating SKN-1

Ferroptosis has been implicated in the occurrence and treatment response of various types of cancer, and targeting ferroptosis has emerged as a promising strategy for cancer therapy

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However, excessive/insufficient mitophagy, inhibition of mitochondrial biogenesis, and an overall reduction in protein synthesis can lead to mitochondrial dysfunction, causing insufficient ATP production or an increased burden of ROS, which in turn cannot meet the cellular demands, ultimately leading to energy deprivation and cell death