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while under pathological conditions, the excessive activation of NF-B may promote the hepatocarcinogenesis and tumor progression (136138)

Indeed, the first oncogene identified (SRC) was also the first Tyr kinase to be discovered 11,12 , and over 50 Tyr kinase inhibitorsincluding Gleevec, one of the earliest successful molecular medicinesare now FDA-approved cancer therapies 13,14

doi: 10.3390/antiox11010150 36 DodsonMCastro-PortuguezRZhangDD

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