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Age-related structural and functional vascular changes are caused by cyclic stress (repeated cardiac contractions cause hemodynamic pressure changes with the greatest impact on the heart near large arteries and pulsatile and circumferential stress)

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Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro

As a result, TZDs decrease insulin resistance (IR) in adipose tissue, muscle, and the liver ( 3.1.2 Adverse effects of using thiazolidinediones One of the main adverse effects associated with PPAR receptor activation is the enhanced proliferation of peripheral adipocytes, which leads to increased uptake of free fatty acids