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This activation triggers the NF-B signaling cascade, leading to a transcriptional upregulation of pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6), chemokines, and adhesion molecules, which in turn recruit more immune cells to the injury site, and driving chronic inflammation and tissue damage (85)

Therefore, it is necessary to overcome the current problems in order to expand the practical usage of EXOs

Furthermore, activated platelets surface-express P-selectin, an adhesion molecule that links innate immunity, inflammation, endothelial activation, and coagulation [59, 60]

The clinical trial participants did not use continuous heart rate monitoring at home

However, treatment with Pycnogenol seems to be an appropriate approach for skin diseases among the local strategies like ascorbic acid, retinoic acid and -tocopherol