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However, these lesions could be distinguished from melanoma in situ by the lack of several features including lateral spread, upward epidermal migration, marked cytologic atypia, finely granular smoky melanin pigment, mitotic figures, and a subjacent host inflammatory response

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Examining the downstream mechanisms through which MC1R-cAMP signalling antagonises inflammatory cytokine production and studying how MT-1s anti-inflammatory effects in skin cells contribute to its photoprotective biology beyond melanin-dependent UV absorption

An increase in IIEF-EF score (e.g., from moderate ED range into mild or normal range) indicates improvement

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