Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-PNP featured monosulfo is azide-activated fluorescent dyes

monosulfo is azide-activated fluorescent dyes for chemoselective labeling and detection of alkyne-tagged molecules

Trametiglue acts as molecular glue

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

CC(C)(C)C(=O)OC1=CC2=C(C=C1)C1(OC(=O)C3=CC=C(C=C13)C(=O)NCCOCCOCCOCC#C)C1=CC=C(OC(=O)C(C)(C)C)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

586 Purity (HPLC) >= 95% Solubility DMSO

Mal-Acetyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-PNP featured monosulfo is azide-activated fluorescent dyesSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as