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Scientists believe that alpha-lipoic acid helps lower blood sugar by promoting processes that can remove fat that has accumulated in muscle cells, which otherwise makes insulin less effective ( Moreover, alpha-lipoic acid may lower the risk of diabetes complications

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Interestingly, this effect is not achieved by affecting the deubiquitinase (DUB) activity of OTUB1 but by impairing its noncanonical activity, binding to the E2 enzyme UBC13[206]

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The present study examines the effect of GSH deficiency on alcohol-induced liver steatosis in Gclm knockout (KO) mice that constitutively have 15% normal hepatic levels of GSH