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The critical role of NAD+ in neuronal function and brain health has made it a central focus of neurodegenerative disease research, with extensive evidence indicating that NAD+ depletion contributes to pathological processes in animal models of Alzheimer's disease, Parkinson's disease, Huntington's disease, and other neurodegenerative conditions

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Interestingly, the same Abdeg was shown to improve radioimaging by shortening the in vivo plasma half-life of a radioactively labeled, tumor-specific human IgG1 mAb in mice, resulting in reduced systemic exposure and thereby improving the imaging contrast in positron emission tomography [121]

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