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BCAAs are reported to directly activate mammalian target of rapamycin (mTOR) signaling 71 and in particular mTOR complex (mTORC), stimulating anabolic processes including protein synthesis and causing insulin resistance and cardiac hypertrophy and dysfunction 72

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And so it needs to be near the site of injury

Exchange of purines in human liver and skeletal muscle with short-term exhaustive exercise

in the control + Sal A group, normal rats were fed on basic diet prepared for 16 weeks and were given Sal A (1 mg/kg/day, dissolved in saline, ip) for the final 4 weeks during 16-week basic diet treatment