Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB dbco-maleimide CA-SS-SiR is a cleavable HaloTag

CA-SS-SiR is a cleavable HaloTag ligand featuring a disulfide bond that can be cleaved using a reducing agent

It reacts with primary amines via carbodiimide activation of the carboxylic acid

At neutral pH

1038/nchem

monosulfo is azide-activated fluorescent dyes for chemoselective labeling and detection of alkyne-tagged molecules

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB dbco-maleimide CA-SS-SiR is a cleavable HaloTagSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine