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left) or of extracts from AGS cells incubated with 50 g/mL [2- 13 C 1 ]-Gly for 24 h prior to mBBr labeling (mB-[ 13 C 1 ]-GSH

Additionally, the novel insights reveal an abnormal secretome in SIRT1-deleted endothelial cells that activates pro-fibrotic tubulointerstitial myofibroblasts and contributes to renal disease, highlighting the significance of distinct paracrine signaling from endothelial cells to adjacent cells and tissues (Lipphardt et al., 2018

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SOD enzymes convert superoxide radicals to hydrogen peroxide (less reactive) for further detoxification by catalase and glutathione peroxidase