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They create energy (ATP), but this process also creates byproducts that can damage the mitochondria themselves

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182 Sultana A, Rahman K, Heyat MBB, et al

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found no CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed (Wang et al., 2019)

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