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doi: 10.4049/jimmunol.1200301

This article demonstrates that bone abnormalities in LSDs are caused by mTORC1 activation and consequent autophagy inhibition that suppresses bone growth

Additionally, SH3BP4 (SH3 domain-binding protein 4) was shown to be a negative regulator of the Rags by interacting with the inactive dimer and preventing its activation during AA starvation (Kim Y.-M