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1.2 Pathogenic mechanisms 1.2.1 Intraocular pressure increase Elevated IOP is one of the main risk factors in glaucoma and is the target of most current treatments

Skjaerbaek C, Frystyk J, Orskov H, Kissmeyer-Nielsen P, Jensen MB, Laurberg S, Moller N, Flyvbjerg A: Differential changes in free and total insulin-like growth factor I after major, elective abdominal surgery: the possible role of insulin-like growth factor-binding protein-3 proteolysis

Thus, the only piece of evidence lacking to draw a similar conclusion for GPX1 is a candidate M pro cleavage site , which most algorithms will fail to find, e.g., if they are highly stringent about requiring a Q in the P1 position (Figure 1)

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