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Notably, total IGF-I and IGFBPs were unchanged over this short-duration window, dissociating the observed bone-growth effect from sustained IGF-1 axis activation in this model

M.FuC.RobbinsN.CowenL

Gittings LM, Sattler R

Therefore, estradiol not only results in increased human epithelial cell proliferation (a process important in tumor growth) but also inhibits the activity of natural killer cells, thus allowing tumor growth [52]