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10.1016/j.rmcr.2020.101063 51 IbaT.LevyJ

These are said to be non-modifiable risk factors

While Tet2 promotes astrocyte differentiation from neural stem cells by demethylating astroglial genes, like Gfap , the transcription factor Olig2 suppresses Tet2 expression, thereby indirectly inhibiting astrocyte formation (He et al., 2020)