MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 57 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCCN=[N]#N)=[N+](C)C)=C1

57 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCCN=[N]#N)=[N+](C)C)=C1

Product Name Thalidomide-O-PEG2-C2-amine HCl Synonyms Thalidomide-4'-O-PEG2-C2-amine HCl CAS Number 1957236-10-0 Related CAS Molecular Formula C19H24ClN3O7 Molecular Weight 441

CA-SS-Lissamine Rhodamine B is a cleavable HaloTag ligand featuring a disulfide bond that can be cleaved using a reducing agent

Datasheet         MSDS       COA

167 SMILES [2H]C([2H])([2H])OC1=CC=C(C=C1)C(O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 57 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCCN=[N]#N)=[N+](C)C)=C1SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,