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Nucleotide-binding and oligomerization domain (NOD)-like receptor thermal protein domain-associated protein 3 (NLRP3) is a cytosolic immune factor that assembles signaling complexes under various pathological conditions, such as metabolic abnormalities, mitochondrial dysfunction, aging, and environmental factors, mediating the activation of inflammatory reactions and cell death [76, 77]

Conversely, both the levels and activity of reactive oxygen species (ROS) are elevated

One expert noted that TB-500 was found to accelerate tumor growth in animal experiments, that other growth-related peptides might carry the same risk, and that other peptides could cause hormonal imbalances

Overall, DPSC injection demonstrated significant advantages over traditional periodontal treatments, offering convenience, minimal invasiveness, improved patient comfort, superior clinical outcomes, and a reduced risk of adverse events such as external inflammatory root resorption

Future studies should further investigate the molecular mechanisms of TSA and its potential clinical applications, aiming to develop novel therapeutic strategies for tubal pregnancy and refractory trophoblastic diseases