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( b ) Metagene plot (mean) for H3K14ac signal at the LSD1 peaks ( 5 kb) across the 498 downregulated genes (top) and 498 unaffected control genes (bottom)

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159,160 Given the aforementioned reactivity of 1,4-NQs in biological systems, it should not be surprising that 1,4-NQs have frequently been observed to induce marked perturbations of metabolism, including ROS production, thiol depletion, alkylation/arylation of numerous target proteins, DNA damage and genotoxicity in diverse biological systems

Therefore, ROS can be considered physiological mediators of great importance in plasticity and signaling, but they can become detrimental to neuronal function when they accumulate excessively in the brain [74]