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Disclosures: Meng Huang: Enanta Pharmaceuticals: Employee, Khanh Hoang: Nothing to Disclose, Jonathan Kibel: Nothing to Disclose, Shucha Zhang: Nothing to Disclose, Lisha Xu: Nothing to Disclose, Yang Li: Nothing to Disclose, Indy Zang: Nothing to Disclose, Daniel Leonard: Nothing to Disclose, Siu-Lung Chan: Nothing to Disclose, Joshua Klaene: Nothing to Disclose, Yat Sun Or: Nothing to Disclose, Li-Juan Jiang: Nothing to Disclose 453 INCREASING RISK OF METABOLIC COMORBIDITIES IN PATIENTS WITH HBV MONOINFECTION, HBV/HCV COINFECTION, AND HBV/HIV COINFECTION: A NATIONWIDE POPULATION-BASED STUDY Jae Yoon Jeong 1 Won Sohn 2 Hyun Woo Oh 2 Hyo Young Lee 3 Na Ryung Choi 1 Yeonjae Kim 4 Jung Hee Kim 5 , 1 Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, 2 Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 3 Inje University Sanggye Paik Hospital, 4 National Medical Center, 5 Dongtan Sacred Heart Hospital of Hallym University Medical Center Background: The use of antiviral therapy in patients with chronic hepatitis B (CHB) has consistently improved survival rates and a positive impact on metabolic comorbidities