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Mitochondrial dysfunction drives metabolic vulnerability in the D2 mouse ON and retina, which in turn triggers AMP-activated protein kinase activation (AMPK), a cellular energy sensor, to activate NF-B signaling and increase expression of inflammatory genes (Powell et al., 2020)

The interactions between high estrogen levels and the gut microbiota (GM) detrimentally affect embryo implantation and fertility by altering the cervical vaginal microenvironment, such as increased pH, bacterial overgrowth, and increased levels of inflammatory factors

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20, May 2010, pp