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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: past, present, and future

Heavy metals catalyze reactions that produce free radicals, which act like molecular shrapnel, tearing through cellular membranes, damaging DNA, and triggering systemic inflammation

It reduces pro-inflammatory cytokines such as IL-1, TNF-, and IL-6 while enhancing anti-inflammatory mediators, including IL-10 and CXCL-1, through modulation of NF-B and MAPK signalling (Chuang et al., 2023

However, the findings and conclusions presented in this paper are those of the author(s) and do not necessarily reflect the views of the NIH or the US Department of Health and Human Services

doi: 10.1038/s41419-023-05855-4 55