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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Rice D, Rodriguez-Restrepo A, Mena G, Cata J, Thall P, Milton D, Correa A, Woodard T, Antonoff M, Hofstetter W, Roth J , Sepesi B, Swisher S, Walsh G, Vaporciyan A, Mehran R

Injections are administered subcutaneously, typically in abdominal fat or other convenient sites

E., Zimmerman, R

FetA produced from hepatocyte by FFAs arrives to adipocytes and acts as an endogenous ligand of TLR4 to promote pro-inflammatory cytokines expression and insulin resistance