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Subcutaneous route: Subcutaneous injection near the injury is the most commonly used route in tissue repair studies

As these substances gain mainstream popularity, the balance between innovation and safety becomes the primary focus

Its relevance to neuropathy is most direct in the metabolic neuropathies, particularly diabetic peripheral neuropathy, where impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction all contribute to nerve damage

10.1016/j.redox.2015.08.009 28

As a highly permeable molecule capable of crossing cellular and mitochondrial membranes, melatonin effectively scavenges reactive oxygen and nitrogen species and modulates the activity of pro-inflammatory cytokines (Srinivasan et al., 2010)