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It means that, for example, certain therapies can have difficulty penetrating the brain

Indeed, in many proliferative cell types, the oxPPP is required to generate ribose-5-phosphate for nucleotide synthesis, whereas G6PDH-deficient chondrocytes can produce this metabolic intermediate by rewiring glucose carbon flux through the non-oxPPP (Fig

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Such a multimodal strategy will facilitate the transition from mechanistic insights to the identification of measurable predictive biomarkers