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Taken together, these findings strongly indicate that O-GlcNAcylation of -synuclein can attenuate pathological aggregation of -synuclein and -synuclein-mediated neurotoxicity in vitro

445 Zhang et al

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When enzyme induction is achieved, the pharmacological effects of a specific drug may be reduced, since not only the metabolism of rifampicin itself, but also the metabolism of the other drug is accelerated The problem arises when doses are increased to reduce the effects of the combined drugs: increased serum concentrations of the combined drugs may possibly produce adverse effect because of the lost enzyme induction if rifampicin is discontinued

Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats