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Proc Natl Acad Sci 106(51):2197221977 Coletta C et al (2012) Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

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We found robust neurodegenerative features in cognitively impaired aged degus, including hippocampal neuronal loss, altered parvalbumin and perineuronal net staining in the cortex, and increased c-Fos neuronal activation in the cortex that is consistent with the neural circuit hyperactivity that are commonly reported in human Alzheimers Disease patients, explained corresponding author Xiangmin Xu, PhD, professor and Chancellors Fellow of anatomy and neurobiology in the UCI School of Medicine, and director of the Center for Neural Circuit Mapping

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This review focuses on the pleiomorphic clinical presentations and the genetic substrate of FIC and proposes a possible diagnostic and therapeutic work-up for this group of diseases, considering the shared factors and therapeutic novelties that may affect them