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Before being approved for use by health authorities, such as the Medicines and Healthcare products Regulatory Agency (MHRA), all medications, including weight loss injections, must undergo rigorous testing and extensive clinical trials

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Blood (2010) 115:4393402

Diabetes : After the surgery, the remaining part of the pancreas may not produce enough insulin, leading to diabetes in about 15-20% patients Complications related to anaesthesia: There is a risk of complications related to anaesthesia, such as allergic reactions or breathing problems

AMPK activation is the same pathway triggered by exercise, caloric restriction, and drugs like metformin