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Its cytosolic domain is released from the Golgi membrane and translocated into the nucleus, inducing its target genes encoding ER chaperones 12

Particularly in Sub-Saharan Africa and other developing nations with a high prevalence of SCD, HU use is widespread

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Recommendation It is recommended to pursue wide-scale multicentre prospective research studies on people with a mutated Glutathione Gene given high amounts of Glutathione and following them over many years to detect any rise in the tumor marker (AFP) of liver cancer, and doing an abdominal ultrasound to detect any hepatic focal lesions or tumors developing over time