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At first glance, it may seem like higher oral doses would work better, but evidence suggests that is not always true

Mol Cell Proteom 20:1000022 Neuzil J, Dyason JC, Freeman R, Dong L-F, Prochazka L, Wang X-F, Scheffler I, Ralph SJ (2007) Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II

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The requirement for hospitalization and mechanical ventilation in patients with severe COVID-19 (mostly in high-risk groups, such as elderly individuals or those with comorbidities) caused acute strains on healthcare systems at the peak of the pandemic, thus leading to national lockdowns and vaccination programs

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